The purpose of the study was to investigate the role of asanas and pranayama on Cardio respiratory variables of College Youths. The subjects for this study were thirty male B.P.Ed students of Seva Bharati Mahavidyalaya, Kapgari, Paschim, Medinipur, West Bengal. The subjects were equally divided into three groups namely two experimental and one control group. The two experimental treatments were assigned at random to two groups i.e. one for Asanas and another for Pranayama and the third group served as control group. The treatment schedule was prepared for ten weeks. The experimental treatments were employed for 30 minutes a day in five days a week for ten weeks duration. Pre and post-test data of all the subjects from three groups were collected before and after the experimental treatment period of 10 weeks. Following variables were selected for the purpose of this study: Sub maximal Heart Rate and VO2Max. The data was analyzed by employing analysis of covariance at the 0.05 level of significance. The result of the study indicates that practice of both Asanas and Pranayama had significant effect on Sub maximal Heart Rate and VO2 Max of the subjects.